Curing the Epilepsies 2013: Pathways Forward 04/17/2013 to 04/19/2013
Natcher Conference Center
Bethesda, Maryland
United States
Mapping Brain Variability in Human Populations. Just as faces differ among different individuals, brain structure varies even among normal individuals, and even more so in disease. This map displays the magnitude and principal directions of anatomical variability in the brain, based on a group of 40 normal subjects scanned with MRI. Pink colors indicate brain regions with large anatomical variability across subjects, blue colors low variability. The ellipsoidal glyphs are elongated along directions in which variation is greatest. The nested, transparent glyphs represent the probabilities of different anatomical variations, and are used to detect abnormal anatomical differences in Alzheimer's Disease. These maps help distinguish pathological changes from normal variations. 
image by Paul Thompson, Andrew Lee, Kiralee Hayashi, Agatha Lee, and Arthur Toga
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Curing the Epilepsies 2013: Pathways Forward

04/17/2013 - 04/19/2013

CuringEpilepsies2013_Programbook (PDF)
Poster_Presentation_List (PDF)
Additional_Participants_List (PDF)

Natcher Center
National Institutes of Health
Bethesda, Maryland

Wednesday April 17, 2013

7:00 AM      Registration and Poster Set-up and continental breakfast

8:00 AM      Welcome 
                 Francis Collins, MD, PhD
                 Director, National Institutes of Health

8:10 AM      Introduction
Story C. Landis, PhD
Director, National Institute of Neurological Disorders and Stroke, NIH

8:20 AM      Overview of the Epilepsy Benchmarks
Dan Lowenstein, MD
University of California San Francisco

SESSION 1: Progress and Future Directions in Understanding the Causes  
Session Chair:  Jeffrey Noebels, MD, PhD

8:30 AM      Introduction
Jeffrey Noebels, MD, PhD
Baylor College of Medicine

8:40 AM      Finding the Cause:  A Sibling’s Perspective
Christina SanInocencio

8:45 AM      Next Generation Sequencing and the Identification of New Epilepsy Genes
David Goldstein, PhD
Duke University

9:10 AM      Autoimmunity in the Epilepsies
Josep Dalmau, MD, PhD
University of Pennsylvania

9:35 AM      Viral Causes of the Epilepsies
Peter Crino, MD, PhD
Temple University

10:00 AM     How Neuroimaging Helps to Identify and Understand the Epilepsies
A. James Barkovich, MD, PhD
University of California, San Francisco

10:25 AM     Summary & Discussion
Jeffrey Noebels, MD, PhD

10:45 AM     Break

SESSION 2:  What Do We Know About the Paths to Epilepsy?
                  Session Chair:  John Huguenard, PhD           

11:05 AM     Introduction
John Huguenard, PhD
Stanford University

11:15 AM     A Mother's Journey
Barbara Kroner, PhD, MPH

11:20 AM     Inherited Epilepsies: Genetic Architecture and Pathways
Sam Berkovic, MD
University of Melbourne

11:45 AM    Epileptogenesis in Genetic Syndromes: Dravet Syndrome
Jack Parent, MD
University of Michigan

12:10 – 1:15 PM   Lunch

1:15 PM       Structural Epileptogenesis
Paul Buckmaster, DVM, PhD
Stanford University

1:40 PM       Epileptogenesis in Acquired Insults
Doug Coulter, PhD
Children’s Hospital of Philadelphia

2:05 PM       Cell-type Specific Control of Neuronal Circuits in Epilepsy
 Ivan Soltesz, PhD
 University of California, Irvine

2:30 PM       What Can We Learn from the Macroscopic Connectome in Epilepsy?
 Matthew Walker, MD, PhD
 University College London

2:55 PM       Summary & Discussion
 John Huguenard, PhD

3:15 PM       Break

SESSION 3: What Do We Know About the Paths to Comorbidities
and SUDEP?
                 Session Chairs: Bruce Hermann, PhD & Frances Jensen, MD

3:35 PM      Introduction
Bruce Hermann, PhD
University of Wisconsin

3:45 PM      Remembering Todd
                 Wendy Parker

3:50 PM      SUDEP:  Human Data and Animal Models
George Richerson, MD, PhD
University of Iowa

4:15 PM      Neurodevelopmental Co-morbidities in the Epilepsies
Sarah Spence, MD, PhD
Boston Children’s Hospital

4:40 PM      Cognitive Co-Morbidities in the Epilepsies: Lessons from the Laboratory
Pierre-Pascal Lenck-Santini, PhD

5:05 PM      Psychiatric Comorbidities of Epilepsy
                 Andrey Mazarati, MD, PhD
                 University of California, Los Angeles

5:30 PM      Chronobiology in Epilepsy: Treating Epileptic Seizures by the Clock
Tobias Loddenkemper, MD
Boston Children’s Hospital               

5:55 PM      Summary & Discussion
Frances Jensen, MD
University of Pennsylvania

6:15 PM       Adjourn and Dinner on Your Own

Thursday April 18, 2013

7:00 AM       Registration and continental breakfast

SESSION 4: What Do We Mean by Cures?
                 Session Co-Chairs:
Robert Fisher, MD, PhD & Elaine Wirrell, MD

8:00 AM      Introduction
Elaine Wirrell, MD
Mayo Clinic

8:10 AM      Epilepsy Surgery: a Chance for a "Cure" but at What Expense?
Craig Miller, MD 

8:15 AM      Special Considerations for Epilepsy Therapy Early in Life: Impact on Brain Development and Long-term Outcomes
Karen Gale, PhD
Georgetown University

8:40 AM      Improvements in the Localization of the Epileptogenic Focus
Ruben Kuzniecky, MD
New York University Comprehensive Epilepsy Center

9:05 AM      Surgical Evaluation and Resection: Advances, New Frontiers, and Questions to be Answered
Edward Chang, MD
University of California, San Francisco

9:30 AM      Epilepsy Device and Engineering Advances: Near-term Applications
Brian Litt, MD
University of Pennsylvania

9:55 AM      Dietary Therapies: Optimizing Efficacy and Extending Clinical Applicability
Jong M. Rho, MD
University of Calgary

10:20 AM    Summary & Discussion
Robert Fisher, MD, PhD
Stanford University 

10:40 AM – 12:00 PM        POSTER SESSION

12:00 – 1:15 PM                 LUNCH

SESSION 5: What Do New Paths to Cures Look Like?
Session Chair: James McNamara, MD

1:15 PM      Introduction
James McNamara, MD
Duke University

1:25 PM      Finding a New Path:  From Heartbreak to Hope
Geraldine Bliss

1:30 PM      Exploiting Knowledge of the Molecular Pathology of Sodium Channel Based Epilepsies for Therapy
Steve Petrou, PhD
University of Melbourne

1:55 PM      Mechanism-Based Therapies in Tuberous Sclerosis Complex
Mustafa Sahin, MD, PhD
Boston Children’s Hospital

2:20 PM      Translation in Fragile X Syndrome
Mark Bear, PhD
Massachusetts Institute of Technology

2:45 PM      Clinical Trials of Therapies for Specific Syndromes and Antiepileptogenesis
Jackie French, MD
New York University Comprehensive Epilepsy Center

3:10 PM     Break

3:30 PM      Prevention Strategies for Acquired Epilepsies
Ray Dingledine, PhD
Emory University

3:55 PM      Novel Opportunities for Disease Modification
Annamaria Vezzani, PhD
Mario Negri Institute for Pharmacological Research

4:20 PM      Summary & Discussion
James McNamara, MD

4:40 – 5:45 PM   Pathways Forward Roundtable
       Moderator: Greg Lewis

Katie Hood, Former CEO, Michael J Fox Foundation
Joel Howell, MD, PhD, University of Michigan
Henrik Klitgaard, PhD, UCB Pharma
Harald Sontheimer, PhD, University of Alabama Birmingham

5:45 PM       Adjourn and Dinner on Your Own

Friday April 19, 2013

7:00 AM       Registration and continental breakfast

Session 6:   Benchmarks for Research on the Epilepsies
Session Co-Chairs – Cara Long, PhD & Dan Lowenstein, MD

8:00 AM      Benchmarks Progress: Perspectives from the Chairs 
                 Dan Lowenstein, with Pete Engel, Ray Dingledine, Brian Litt,
                 Anne Berg, Amy Brooks-Kayal

8:30 AM      Introduce Breakout Sessions

8:35 – 10:15 AM      Benchmark Breakout Sessions

                 Breakout Session 1:  Benchmark Area I - 
                 Prevent Epilepsy and its Progression
                    Breakout Chair: Pete Engel, MD
                    Breakout Moderator: Ann Poduri, MD, MPH
                    Virtual Moderator: Aristea Galanopoulou, MD, PhD

Breakout Session 2:  Benchmark Area II - 
                 Develop New Therapeutic Strategies and Optimize 
                 Approaches to Cure Epilepsy
                    Breakout Chair: Brian Litt, MD
                    Breakout Moderator: Karen Wilcox, PhD
                    Virtual Moderator: Greg Worrell, MD, PhD

Breakout Session 3:  Benchmark Area III -                  
                 Prevent, Limit and Reverse the Co-morbidities Associated
                 with Epilepsy and its Treatment
                    Breakout Chair: Amy Brooks-Kayal, MD
                    Breakout Moderator: Elson So, MD
                    Virtual Moderators: Dan Drane, PhD 
                                               Alica Goldman, MD, PhD

10:15 AM     Break

10:35 - 11:45 AM     Breakout Group Summaries and Discussion

10:35 AM     Breakout Group 1
Ann Poduri, MD, MPH

10:50 AM     Breakout Group 2 
Karen Wilcox, PhD

11:05 AM     Breakout Group 3  
Elson So, MD

11:20 AM     Full Group Discussion: New Opportunities and Needs Beyond the Current Benchmarks                 

11:50 AM     Summary & Next Steps
 Dan Lowenstein, MD

12:00 PM     Closing Remarks
Walter Koroshetz, MD
Deputy Director, National Institute of Neurological Disorders and Stroke, NIH

12:15 PM     Conference Adjourns

12:45 - 3:00 PM  Working Meeting of Benchmark Stewards


Poster Session

04/18/2013 - 04/18/2013

Break-out session 1: Benchmark Area I - Prevent epilepsy and its progression


Break-out session 2: Benchmark Area II - Develop new treatments to cure epilepsy


Break-out session 3: Benchmark Area III - Comorbidities and SUDEP


Working Meeting of Benchmark Stewards