Travel Fellowship

Please upload the Travel Fellowship application as a PDF file on the REGISTRATION tab.

Background

     In 2014, the National Institutes of Health (NIH) awarded six cooperative agreement grants (U54) to support Data and Signature Generating Centers which are part of the NIH Library of Integrated Network-based Cellular Signatures (LINCS) program.  The LINCS program aims to catalog and analyze cellular function and molecular activity in response to perturbing agents, such as drugs, toxicants, and genetic factors, which can alter the cellular signature.         
One of the Data and Signature Generating Centers, NeuroLINCS is focused on characterizing induced pluripotent stem cell (iPSC) lines and differentiated cell types derived from healthy (control) subjects and patients with neurological disorders such as Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA). Technologies employed by the NeuroLINCS center include transcriptomics (RNA-Seq), proteomics (SWATH-MS), epigenomics (ATAC-Seq) and robotic imaging.  The cell lines studied to date include iPSCs from healthy control subjects (0000iCTR, 0014iCTR, 0025iCRT, and 0083iCTR) and iPSC lines from ALS patients with a C9ORF72 pathogenic hexanucleotide repeat expansion (0028iALS, 0029iALS, 0030iALS, 0052iALS), and SMA patients with SMA type 1 disease (0032iSMA, 0077iSMA and 0083iSMA).  Additional de-identified clinical information on the iPSC lines used by NeuroLINCS can be found on the Cedars-Sinai iPSC core site

Data and Tools Available

      As of January 3, 2016, three data releases (September 2015, June 2015 and December 2015) are available from the NeuroLINCS center and include data from iPSC lines and motor neurons differentiated from several of these lines. Current available data includes iPSC transcriptomic, epigenomic, and proteomic data from healthy controls, iPSC transcriptomic data from ALS and SMA individuals and differentiated motor neuron transcriptomic data from healthy control individual iPSCs.  Future releases will include transcriptomic, epigenomic, and proteomic data on remaining iPSC lines and omic and imaging data on differentiated motor neurons from ALS and SMA individuals.  Metadata describing experimental conditions for assays employed, cell line growth, motor neuron differentiation and quality assurance measures are also available. Tools and apps developed by the BD2k-LINCS data coordination and integration center are available to assist with analysis of NeuroLINCS data. 

The Travel Fellowship Application should include the following and must be received by February 12, 2016:

Name (first and last names):
Email Address:
Institution Name, Department and your affiliation (undergraduate or graduate student or postdoctoral fellow):
Abstract of Research Proposal:
List of NeuroLINCS datasets to be used (current and future releases):
Research hypothesis and analysis strategy:

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