General Information

Welcome to the NIH Quantitative Systems Pharmacology and Neurotherapeutics Drug Discovery Workshop!

Organized and sponsored by: NINDS in collaboration with NIA, NIMH, NIDA and NCATS

Date: July 26-27, 2017

Location: Bethesda North Marriott Hotel & Conference Center

                  Conference Room: Salon C

                  5701 Marinelli Road, Bethesda, MD 20852

What is Quantitative Systems Pharmacology (QSP)?

QSP is the merger of systems biology and systems pharmacology approaches for the purpose of facilitating drug discovery and development for complex diseases that have not been defined by a single molecular target. 

Systems biology can be used to elucidate a network of genes, proteins or neural pathways and then model the responses of that network to environmental, chemical or genomic perturbations.  Information gained from this approach is useful for the identification of therapeutic targets and biomarkers for disease, utilizing the horizontal integration of multivariate data.  A systems pharmacology approach allows the vertical integration of systems biology data from molecular to physiological levels.  Information gained from a merged systems biology and pharmacology approach would allow not only drug target identification, but would also allow more efficient prediction of PK/PD relationships that would lead to more accurate human dose projections.  In addition, this merged discipline would allow better prediction of toxicity, translating “omic” or phenotypic screening data to animal models.  Finally, a merged systems biology and pharmacology approach could facilitate better identification of biomarkers used to better select and stratify patients in clinical trials.

What are the goals of the workshop? 

·       To assess the feasibility of a QSP approach as a model to improve the success of CNS Drug Discovery and Development

·       To identify roadblocks and gaps in the application of the QSP model to CNS Drug Discovery and Development

·       To identify opportunities to address these roadblocks and gaps

Information for Speakers, Poster Presenters and Session Chairs

·       Please go to the registration tab and fill out the information requested by July 21, 2017

·       Submit your brief biosketch, title and abstract during registration by June 9, 2017. This is a one-time event and files can only be uploaded in PDFs. Please contact Oreisa O’Neil at oneilo@ninds.nih for any concerns or questions regarding registration and uploads.

·       Submit your slides (final presentation) to Oreisa O’Neil at oneilo@ninds.nih.gov by July 5th, 2017

·       Mr. Tim Lyden will contact you about your travel beginning the week of May 22, 2017

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