General Information

     The National Institutes of Health (NIH) Library of Integrated Network-based Cellular Signatures (LINCS) program aims to create a network-based understanding of biology by cataloging changes in gene expression and other cellular processes that occur when cells are exposed to a variety of perturbing agents, and by using computational tools to integrate this diverse information into a comprehensive view of normal and disease states that can be applied for the development of new biomarkers and therapeutics. By generating and making public data that indicates how cells respond to various genetic and environmental stressors, the LINCS project will help us gain a more detailed understanding of cell pathways and aid efforts to develop therapies that might restore perturbed pathways and networks to their normal states.

     The first day of the workshop will bring together the six LINCS Data and Signature Generation Centers and the BD2K-LINCS Data Coordination and Integration Center (DCIC) to review progress to date and discuss the next steps for data integration and analysis across the centers.  The afternoon of the first day and the morning of the second day of the workshop will include an outreach program with experts in stem cell biology, and big data management and analysis and will focus on the use of current datasets.

 

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