General Information

The objective of this workshop is to determine “essential” questions of basic-disease research (mechanisms, etiologies, biological pathways) in essential tremor (ET) and identify approaches towards them. ET is extremely common, although prevalence data on essential tremor are surprisingly difficult to interpret, with estimates between 0.08-220 cases/1000 persons, a variation of 2750-fold (Chen and Swope, 2003). Historically termed "Benign Essential Tremor", it is anything but benign, and is the cause of significant disability. Despite this, the field remains largely descriptive.

ET remains relatively unstudied in terms of etiology, reducing rigor of clinical studies. It is assumed to be cerebellar, but data are not recent. It is also not clear if it is on a spectrum of physiological (normal) tremor or a distinct entity. Treatments exist, but the levels of responsiveness and reasons for unresponsiveness remain unknown. Deep brain stimulation is used frequently to treat ET: an opportunity exists to better explore circuitry of this disorder. Genetics and other tools can be employed to better understand disease etiology and potential stratification of patients for clinical trials.

Version: 2.0.0