Post-Traumatic Epilepsy: Models, Common Data Elements and Optimization

03/18/2021 - 03/19/2021

Post-Traumatic Epilepsy: Models, Common Data Elements and Optimization

Neuroscience Building
6001 Executive Boulevard
Bethesda, MD 20892-9535

March 18-19, 2021

Chairs:  Claudia Robertson, MD PhD (Baylor) and Aristea Galanopoulou, MD PhD (Einstein)


March 18, 2021  Download Meeting Agenda Here


7:00 AM        Registration and Badging                                       NIH Staff/Security                     

8:00 AM        Welcome from Walter, Introduction and Meeting Chairs

                                         Challenge to Audience      

8:30 AM        Remarks from Other Interested Parties                 (ILAE, EFA, AES)


PTE:  The Clinical Picture                                          Moderator:  Paul Vespa

9:00 AM        Epidemiology of PTE                                               Nathalie Jett (MT Sanai)

9:20 AM        Review of Current Data Collection                          Geoff Manley (UCSF)

                     And Standard of Care                            

9:40 AM        Challenges for Clinical Studies of PTE                    Pavel Klein (Bethesda)


10:00 AM     Break


Ongoing Research Efforts in PTE                              Moderator:  Laura Lubbers

10:30 AM      Overview of EpiBios4Rx                                          Pete Engel (UCLA)

10:50 AM      Overview from the Military                                        Karen Parko (DOD)

11:10 AM      Overview of CURE                                                    Lauren Harte-Hargrove (CURE)

11:30 AM      TRACK TBI and PTE                                                Ramon Dias-Arrastia (Penn)


12:00 PM      Lunch          


Pre-Clinical Challenges (Models)                               Moderator:  Lisa Coles

1:00 PM        TBI Models:  What are we modeling                        Ed Dixon (Pitt)

1:30 PM        Higher Complexity Models                                        John Povlishock (VCU)

2:00 PM        What Constitutes a valid model of PTE                    Asla Pitkännen (E. Finland)


2:30 PM         Break


Pre-Clinical Challenges (CDEs)                                Moderator: Neil Harris

3:00 PM        Current state of Preclinical CDE’s                          Neal Harris (UCLA)

3:30 PM        Optimizing Preclinical CDE’s                                  Aristea Galanopoulou (Einstein)

4:00 PM        Optimizing Predictive Value of CDE’s                    Terry O’Brien (Melbourne)


4:30 PM        Breakout Session I:  Optimizing Preclinical Studies to better model clinical observations: 
                       Moderators:  John Wolf and Aristea Galanopoulou


6:00 PM        Adjourn




March 19,  2021


7:00 AM        Registration and Badging                                        NIH Staff /Security


8:00 AM        Welcome and Review of Previous Day   Meeting Chairs

          Address by other parties (NIH, DOD, CURE, etc.)

8:30 AM        Review of Breakout Session                                     John Wolf and Aristea Galanopoulou


Challenges of Large Datasets                                   Moderator:  Susan Gregurick

 9:00 AM       NIH Strategic Plan for Data Science                       Susan Gregurick (NIH)

 9:20 AM       Translating Biological Data into Binary Data          Art Toga (USC)

 9:40 AM       User Friendly, Searchable Databases                    Zack Grinspan (Cornell)

10:00 AM      Analyzing Large Preclinical Datasets                     Adam Furgusen (UCSF)

10:20 AM      Panel Discussion (Handling Large Datasets)


10:40 AM       Break


PTE: Improving the Clinical Picture                          Moderator:

11:00 AM      Clinical Biomarkers of PTE                                     Paul Vespa (UCLA)

11:20 AM      Annotating Clinical Data                                          Satya Sahoo (Case Western)

11:40 AM      Optimizing Clinical Studies                                      Nico Moshe (Einstein)


12:00 PM      Working Lunch and Breakout Session

                      Breakout Session II: Optimizing Clinical Studies to Prevent PTE
         Moderators:  Geoff Manley and Pavel Klein


2:00 PM        Regroup and Review of Session II                        Geoff Manley and Pavel Klein

2:30 PM        Challenges Going Forward                                    Claudia Robertson and

              Aristea Galanopoulou         

3:00 PM        Adjourn



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