Agenda

2019 NIH-Japan-JSPS symposium
Advances in Inflammation Research
Lipsett Amphitheater, Bethesda MD USA

October 28th (Mon) and 29th (Tue), 2019

Day 1 (Monday, October 28th)
7:30 am Registraion  open

8:00-8:30 am: Opening remarks
Michael Gottesman (NIH Deputy Director for Intramural Research)
Takaaki Akaike (Vice Dean of Tohoku University Graduate School of Medicine)
Kohji Hirata (Director of JSPS Washington, DC office)

8:30-9:00 am: Plenary session
Keiji Tanaka (Tokyo Metropolitan Institute of Medical Science); "The Proteasome: Stress and Phase Separation"

Scientific Session 

9:00-10:15 am:  Session #1: Inflammation and Regulation
9:00-9:30 am   Keji Zhao (NHLBI): “Negative regulatory mechanism of Ifng expression"
9:30-10:00 am  Hisashi Arase (Osaka University): "Chaperon-like function of MHC class II molecules for misfolded proteins: A new mechanism for autoimmune diseases”
Young investigator short talks:
10:00-10:07 am  Saori Fujiwara (NCI): "Chromatin landscape analysis using ATAC on stored cyropreserved cells and tissues" (Poster #9)
10:07-10:14 am  Masaki Hosogane (NCI): "5'UTR mRNA acetylation regulates translation initiaion" (Poster #11)

10:15-10:45 am: Coffee Break

10:45 am-12:00 pm:  Session #2: Inflammation, Mitochondria, and Programmed Cell Death
10:45-11:15 am  Shiori Sekine (University of Pittsburg/NINDS):  “PINK1 import regulation at a crossroad of mitochondrial fate”
11:15-11:45 am  Takaaki Akaike (Tohoku University): “Reactive sulfur species antagonizing and coping with inflammation and oxidative stress”
Young investigator short talks
11:45-11:52 am  Shigetoshi Yokoyama (NCI): "A novel pathway of LPS uptake through syndecan-1 leading to pyroptotic cell death" (Poster #41)
11:52-11:59 am  Akiko Taira-Sunahara (NIDDK): "Gsalpha deficeincy in pancreatic alpha cells leads to enlarged islets" (Poster #32)

Photography session for all attendees

12:10-1:00 pm: Lunch

1:00-3:00 pm: Poster session (FAES classroom 1+2, 4, 6+7)
Refreshment will be provided (coffee)

3:00-4:15 pm:  Session #3: Inflammation and Autoimmunity
3:00-3:30 pm  Jennifer Martinez (NIEHS): “Non-canonical autophagy and immunotolerance”
3:30-4:00 pm  Kenji Kabashima (Kyoto University): “Cutaneous immune response to external and internal stimuli”
Young investigator short talks
4:00-4:07 pm  Hirotsugu Oda (NHGRI): "Cleavage-resistant RIPK1 metations cause autoinflammation" (Poster #25)
4:07-4:14 pm  Yosuke Tona (NIDCD): Live imaging of centriole movements in nascent utricular hair cells" (Poster #37)

4:15-5:30pm: Session #4: Inflammation and Inflammatory Signaling
4:15-4:45 pm  Ronald Germain (NIAID): “Dynamic intravital imaging reveals how resident tissue macrophages prevent neutrophilic inflammation to maintain organ function”
4:45-5:15 pm  Yumiko Oishi (Nippon Medical School): "Coordinated regulation of inflammatory response and lipid metabolism in macrophage"  
Young investigator short talks
5:15-5:22 pm  Tatsuma Ban (Yokohasma City U): "IRF5 as a therapeutic target that overcomes the limitation of current therapies in SLE" (Poster #4)
5:22-5:29 pm  Shuichi Aoki (Tohoku U): "Placental growth factor increases desmoplasia, tissue stiffness and promotes tumor progression via Akt activation in intrahepatic cholangiocarcinoma" (Poster #2)

6:00-8:30 pm:  Reception at Building 60, the Cloisters (invited speakers only)

Day 2 (Tuesday, October 29th)
Scientific session

8:30 am-9:45 am:  Session #5: Inflammatory Diseases I
8:30-9:00 am  Rachel Caspi (NEI): “Microbiota and the eye - the yin and the yang”
9:00-9:30 am  Yoichiro Iwakura (Tokyo University of Science): “The role of Dectin-1 in the homeostasis of the intestinal immune system”
Young investigator short talks
9:30-9:37 am  Samiul Alam (FDA): "Susceptibility of aging mice to listeriosis: Role of anti-inflammatory responses with enhanced Treg-cell expression of CD39/CD73 and Th-17 cells" (Poster #1)
9:37-9:44 am  Murali Palanat (NCI): "The splicing factor U2AF1 contributes to cancer progression through a non-cannonical role in translation regulation" (Poster #27)

9:45-10:45 am: Session Commemorating the 2011 Great East Japan Earthquake and Tsunam
9:45-10:15 am  Mami Ishikuro (Tohoku Medical Megabank Organization, Tohoku University): "What impact does the Great East Japan Earthquake have on our health?"
10:15-10:45 am  Nobuo Fuse  (Tohoku Medical Megabank Organization, Tohoku University): "The Tohoku Medical Megabank Project to realize personalied medicine"

10:45-11:15 am: Coffee Break

11:15 am-12:30 pm:  Session #6: Inflammation and Neurological Diseases
11:15-11:45 am  Daniel Reich (NINDS): “Imaging lesion repair in multiple sclerosis”
11:45 am-12:15 pm  Yoshihisa Yamano (St. Marianna University): “Anti-CCR4 monoclonal antibody therapy in HTLV-1-associated neuroinflammatory disease”
Young investigator short talks
12:15-12:22 pm  Kiyoshi Hirahara (Chiba U): "CD103hi Treg cells regulate lung fibrotic reponse induced by CD103lo tissue-resident pathogenic CD4 T cells" (Poster #10)
12:22-12:29 PM  Takeshi Kawabe (Tohoku U): "Differentiation of innate T-bet hi memory-phenoype CD4+ T lymphocytes is promoted by homeostatic IL-12 derived from CD8alpha+ type 1 dendritic cells in steady state" (Poster #15)

12:30-1:30 pm: Lunch

1:30-2:45 pm:  Session #7: Inflammatory Diseases II
1:30-2:00 pm  Niki Moutsopoulos (NIDCR): “Immunity at the oral mucosal barrier”
2:00-2:30 pm Hiroshi Kiyono (University of Tokyo): “Mucosal multi-immunological ecosystem to vaccine development”
Young investigator short talks
2:30-2:37 pm  Aseel Marahleh (Tohoku U): "TNF-alpha directly enhances osteocyte RANKL expression and promotes osteoclast formation" (Poster #22)
2:37-2:44 pm Kazuma Ito (Tohoku U): "Mechanisms of ABCB1 in acquisition of Taxane resistance in cancer cells" (Poster #13)

2:45-3:00 pm: Closing Remarks 
Michael Gottesman

3:00-4:30 pm: Coffee Break/NIH Tour

4:30-6:00 pm: Career Development Workshop for Young Investigators (targeted for both NIH and Japanese postdocs and students)
"Compelling CV writing workshop - Put your best foot forward!"  Location: Bldg 30/Rm 117

No Federal funds are used to provide refreshments and lunches for this symposium. Funds provided by co-sponsors, the Foundation for Advanced Education in the Sciences (FAES), and the Japan Society for the Promotion of Science (JSPS).