Agenda

Alzheimer's Disease-Related Dementias Summit 2019

03/14/2019 - 03/15/2019

Agenda

Thursday, March 14, 2019   
7:00 a.m.        Registration

INTRODUCTION

8:00 a.m.    Welcoming Remarks and Introduction
        Walter Koroshetz, MD, Director, National Institute of Neurological Disorders and Stroke

8:10 a.m.     Perspective
        Laura Gitlin, MD, PhD, Chair, Advisory Council on Alzheimer’s Research, Care, and Services

8:20 a.m.    Progress and Updating Research Recommendations for the Alzheimer’s Disease-Related Dementias
        Julie Schneider, MD, MS, Scientific Chair, and Roderick Corriveau, PhD, NIH Lead, ADRD Summit 2019, National Institute of Neurological Disorders and Stroke

SESSION 1: Multiple Etiology Dementias – Diagnosing Dementia in the 21st Century
    Chairs: David Knopman, MD, and Kate Possin, PhD

8:40 a.m.    Session Introduction – Revised Recommendations: Reconciling the Gap between Aspirational and Operational Goals
        David Knopman, MD

8:47 a.m.    Recommendation 3: Advance Basic and Clinical Research in MED
        David Knopman, MD

8:59 a.m.    Recommendations 1 and 2: Progress and Next Steps in Detection and Diagnosis of Cognitive Impairment and Dementia
        Kate Possin, PhD and Alireza Atri, MD, PhD

9:15 a.m.    Recommendation 6: Implementing Effective Dementia Care
        Kate Possin, PhD

9:27 a.m.    Recommendation 4: Progress and Work Needed to Increase the Dementia Capable Workforce
        Heather Snyder, PhD

9:39 a.m.    Recommendation 5: Conduct Intervention Studies to Mitigate Reversible Causes of Cognitive Dysfunction
        Sharon Inouye, MD, MPH and David Knopman, MD

9:55 a.m.    Open Microphone Discussion and Panel – Multiple Etiology Dementias
        Alireza Atri, MD, PhD; Patricia Boyle, PhD; Cynthia Carlsson, MD, MS; Sharon Inouye, MD, MPH; David Knopman, MD; Kate Possin, PhD, Heather Snyder, PhD

10:20-10:40 a.m.    BREAK

SESSION 2: Health Disparities in AD/ADRD
    Chairs: Lisa Barnes, PhD and Hector Gonzalez, PhD

10:40 a.m.     Introduction
        Lisa Barnes, PhD and Hector Gonzalez, PhD

10:50 a.m.    Recommendations 1 and 2: Assessment
        Jennifer Manley, PhD

11:06 a.m.    Recommendations 3 and 4: Epidemiology and Pathway Analyses Toward Culturally Appropriate Interventions
        Rebecca Gottesman, MD, PhD

11:22 a.m.     Recommendations 5 and 6: Monitoring Trends
        Elizabeth Rose Mayeda, PhD, MPH

11:38 a.m.     Recommendation 7: Workforce Development
        Luis Medina, PhD

11:54 a.m.    Open Microphone Discussion and Panel – Health Disparities in AD/ADRD
         Lisa Barnes, PhD; Myriam Fornage, PhD; Hector Gonzalez, PhD; Rebecca Gottesman, MD, PhD; J. Taylor Harden, PhD, RN; Jennifer Manly, PhD; Elizabeth Rose Mayeda, PhD, MPH; Luis Medina, PhD

12:20-1:20 p.m.    LUNCH ON YOUR OWN

SESSION 3: Lewy Body Dementias
    Chair: Bradley Boeve, MD and Carol Lippa, MD

1:20 p.m.    Introduction
        Bradley Boeve, MD and Carol Lippa, MD

1:30 p.m.    Clinical Science – Progress and Changes to Recommendations 1-4
        Jennifer Goldman, MD, MS; Kirk Frey, MD; Dennis Dickson, MD

2:05 p.m.    Basic Science – Progress and Changes to Recommendations 5-8
        Douglas Galasko, MD, Sonja Scholz, MD, PhD; Mark Cookson, PhD

2:40 p.m.    Open Microphone Discussion and Panel – Lewy Body Dementias
        Bradley Boeve, MD; Mark Cookson, PhD; Dennis Dickson, MD; Kirk Frey, MD; Douglas Galasko, MD; Jennifer Goldman, MD, MS; Peter Lansbury Jr, PhD; Carol Lippa, MD; Sonja Scholz, MD, PhD; Angela Taylor, BMus; Daniel Weintraub, MD

3:00-3:20 p.m.    BREAK               

SESSION 4: Dementia Nomenclature
    Chairs: Ronald Petersen, MD, PhD and Angela Taylor, BMus

3:20 p.m.    A Rising National Priority: Recommendations to Form Integrated Workgroups on Nomenclature in Research, Clinical Practice, and Society
        Angela Taylor, BMus

3:25 p.m.    Stakeholder Engagement Strategy: The Needs of the Research Community
        Ronald Petersen, MD, PhD

3:40 p.m.    Translating the Science into Clinical Practice
        James Leverenz, MD

3:48 p.m.    Living with a Dementia Diagnosis: The First-Person Experience
        Cynthia Huling Hummel, BS, MDiv, DMin

3:53 p.m.    Insights from a Caregiver
        Mark Herthel, BS

3:58 p.m.    Cultural Considerations: Giving Meaning to and Responding to Dementia
        Peggye Dilworth-Anderson, PhD

4:06 p.m.     Stigma: Considerations of Ethics and History
        Jason Karlawish, MD, Cara Fallon, PhD, MPH


4:14 p.m.     Categories and Controversies: Insights from DSM-5
        Dominic Sisti, PhD

4:22 p.m.     Integration of Stakeholder Input and Next Steps
        Sandra Weintraub, PhD, ABCN/ABPP

4:30 p.m.     Open Microphone Discussion and Panel – Dementia Nomenclature
        Peggye Dilworth-Anderson, PhD; Mark Herthel, BS; Cynthia Huling Hummel, BS, MDiv, DMin; Jason Karlawish, MD; James Leverenz, MD; Ron Petersen, MD, PhD; Dominic Sisti, PhD; Angela Taylor;
Sandra Weintraub, PhD, ABCN/ABPP

5:00 p.m.        Adjourn Day 1

Friday, March 15, 2019

7:30 a.m.        Registration

SESSION 5: Vascular Contributions to Cognitive Impairment and Dementia
    Chairs: Donna Wilcock, PhD and Jeff Williamson, MD, MHS

8:00 a.m.    Introduction and Overview of Recommendations
        Donna Wilcock, PhD

8:10 a.m.    Basic Science and Mechanisms Recommendations
        Andy Shih, PhD and Roxanna Carare, MD, PhD

8:30 a.m.    Clinical Science Recommendations
        Kristine Yaffe, MD and Eric Smith MD, MPH

8:50 a.m.    Translational Science Recommendations
        Jeff Williamson, MD, MHS

9:10 a.m.    Open Microphone Discussion and Panel – VCID
        Roxanna Carare, MD, PhD; Susan Catalano, PhD; Rebecca Gottesman, MD, PhD; Douglas Gould, PhD; Anne Leonard, MPH, RN; Henrieta Scholtzova, MD, PhD; Andy Shih, PhD; Eric Smith, MD, MPH; Heather Snyder, PhD

9:40-10:00 a.m.        BREAK       

SESSION 6: Frontotemporal Lobar Degeneration
    Chairs: Leonard Petrucelli, PhD and Adam Boxer, MD, PhD

10:00 a.m.    Introduction and Changes to Basic Science Recommendations 1-4
        Leonard Petrucelli, PhD

10:05 a.m.    Basic Science: Advances in tau Biology
        Anthony Fitzpatrick, PhD

10:15 a.m.    Basic Science: Advances in FTLD C9ORF72, and GRN Biology
        Jeff Rothstein, MD, PhD and Michael Ward, MD, PhD

10:25 a.m.    Basic Science: Single Cell ‘Omic Analysis for FTLD
        Manolis Kellis, PhD

10:35 a.m.    Open Microphone Discussion and Panel – Basic Science of FTLD
        Patrick Brannelly, MBA; Anthony Fitzpatrick, PhD; Manolis Kellis, PhD; Rodney Pearlman, PhD; Leonard Petrucelli, PhD; Jeff Rothstein, MD, PhD; Nadine Tatton, PhD; Michael Ward, MD, PhD

10:50 a.m.    Changes Made to Clinical Science Recommendations 5-8
        Adam Boxer, MD, PhD

10:55 a.m.    Clinical Science: Biomarkers
        Henrik Zetterberg, MD, PhD and Jon Rohrer, MD, PhD

11:05 a.m.    Clinical Science: Genetics and Natural History Studies
        Bradley Boeve, MD

11:15 a.m.    Clinical Science: Clinical Trials
        Adam Boxer, MD, PhD

11:25 a.m.    Open Microphone Discussion and Panel – Clinical Science FTLD
        Adam Boxer, MD, PhD; Patrick Brannelly, MBA; Nick Fox, MD; Rodney Pearlman, PhD; Jon Rohrer, MD, PhD; Holly Soares, PhD; Nadine Tatton, PhD; Henrik Zetterberg, MD

11:40-12:40 p.m.     LUNCH ON YOUR OWN

SESSION 7: Emerging Scientific Topics
    Chairs: Kristen Dams-O’Connor, PhD and Julie Schneider, MD, MS

12:40 p.m.    Introduction to TDP-43 in Common Dementias & Recommendations 1-4
        Julie Schneider, MD, MS

12:45 p.m.    TDP-43 in Common Dementias: Rationale for Clinical Recognition and Biomarkers Studies
        Julie Schneider, MD, MS

12:50 p.m.    Rationale for Studying Risk Factors, Genetic Drivers and Pathologic Phenotypes of TDP-43 in Common Dementias
        Pete Nelson, MD, PhD

1:00 p.m.    Rationale for Basic Science and Animal Model Studies Specifically Targeted Toward TDP-43 in Common Dementias
        Aaron Gitler, PhD

1:10 p.m.    Open Microphone Discussion & Panel – TDP-43 in Common Dementias
        Aaron Gitler, PhD; Pete Nelson, MD, PhD; Julie Schneider, MD, MS

1:30 p.m.    Introduction to TBI and AD/ADRD Risk
        Kristen Dams-O’Connor, PhD

1:40 p.m.    Summary of NIH/VA-ORD Workshop: TBI as a Risk Factor for AD/ADRD among Veterans
        Kristen Dams-O’Connor, PhD

1:45 p.m.    Recommendations 5-8 for the Study of TBI and AD/ADRD Risk
        Kristen Dams-O’Connor, PhD

1:50 p.m.    Open Microphone Discussion and Panel – TBI and AD/ADRD Risk
        Kristen Dams-O’Connor, PhD; Mary Jo Pugh, PhD, RN; Douglas H. Smith, MD; Henrik Zetterberg, MD, PhD

2:20-2:30 p.m.        BREAK

WRAP-UP


2:30 p.m.    Scientific Chair’s Highlights and Cross-Cutting Themes
        Julie Schneider, MD, MS, Scientific Chair

2:55 p.m.    Further Public Input and Open Microphone Discussion
        Lisa Barnes, PhD; Bradley Boeve, MD; Adam Boxer, MD, PhD; Kristen Dams-O’Connor, PhD; Hector Gonzalez, PhD; David Knopman, MD; Carol Lippa, MD; Ronald Petersen, MD, PhD; Leonard Petrucelli, PhD; Kate Possin, PhD; Julie Schneider, MD, MS; Angela Taylor, BMus; Donna Wilcock, PhD; Jeff Williamson, MD, MHS

3:20 p.m.    Conclusion of ADRD Summit 2019
Version: 2.1.0