Agenda

Meeting Agenda (PDF)

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07/26/2017 - 07/27/2017

  Agenda


Welcome

Amir Tamiz,PhD, Associate Director, NINDS
07/26/2017

Introduction

8:30 am - 8:50 am Walter Koroshetz,MD (Director, NINDS) & Richard Hodes,MD (Director, NIA)
07/26/2017

Meeting Overview: Goals and Logistics

8:50 am - 9:00 am Pelleymounter PhD, NINDS, Workshop Organizer
07/26/2017 - 07/27/2017

Quantitative Systems Pharmacology (QSP): History, Relationship to Systems Biology and Applications to CNS Drug Discovery

Chair: Piet van der Graaf, PhD, Certara, Workshop Co-Chair 9:00 -9:40 AM
07/26/2017          

Time

Event

Presenters

9:00-9:20 AM

QSP: History, Relationship to Systems Biology and Applications to CNS Drug Discovery

Piet van der Graaf, PhD, Certara, Workshop Co-Chair

9:20-9:40 AM

Topic: Evolution of Systems Biology to Pharmacology in Drug Discovery and Systems Medicine

Eric Schadt, PhD, Icahn School of Medicine, Mount Sinai


NIH Initiatives in Systems Biology and QSP: Background and Current Status (QSP, Accelerated Medicines Partnership, NINDS and NCATS)

9:40 am - 10:15 am Suzana Petanceska, (NIA), Margaret Sutherland, (NINDS), Ilyas Singec (NCATS)
07/26/2017  

Time

Event

Presenters

9:40-9:50 AM

NIH Initiatives in Systems Biology and QSP:  Accelerated Medicines Partnership (NIA)

Suzana Petanceska, PhD, NIA, Workshop Co-Chair

9:50-10:05 AM

NIH Initiatives in Systems Biology and Pharmacology:  NINDS

Margaret Sutherland, PhD, NINDS

10:05-10:15 AM

NIH Initiatives in Systems Biology and Pharmacology: NCATS

Ilyas Singec, MD PhD, NCATS


Overview: Sytems Pharmacology Approaches to CNS Disease

Chair: Roberta Brinton, PhD, University of Arizona 10:30 am - 12:30 pm
07/26/2017               

Time

Event

Presenters

10:30-10:45 AM

Overview

Roberta Brinton, PhD, University of Arizona

10:45-11:00 AM

Alzheimer’s Disease (Academic Perspective)

David A Bennet, MD, Rush Medical College, Rush University

11:00-11:15 AM

Systems Pharmacology Approaches in Alzheimer's Disease: Industry Perspective

Kapil Gadkar, PhD, Genentech

11:15-11:30 AM

Parkinson’s Disease (Academic Perspective)

Clemens Scherzer, MD, Harvard Medical School

11:30-11:45 AM

Metabolic modeling of a glucocerebrosidase activator for a genetic subtype of Parkinson’s Disease

Peter Lansbury, PhD, Lysosomal Therapeutics

11:45-12:00 PM

Multi-Omics, Multi-Center Data Integration to Dissect Subtypes and Causal Networks in ALS

Karen Sachs, PhD, Stanford University School of Medicine

12:00 12:15 PM

The Psychiatric Genomics Consortium: using psychiatric genetics to find drug targets and new drug indications

Gerome Breen, PhD, Kings College of London

12:15-12:30 PM

How Biomarker Discovery has informed Systems Pharmacology for Migraine

 

Michael Oshinsky, PhD, NINDS

12:30-1:30 PM

Lunch

 

        

Neurotherapeutic Target Identification and Deconvolution

Chair: Kalpana Merchant, PhD, TransThera Consulting Co. 1:30 pm -3:00 pm
07/26/2017       

             

Time

Event

Presenters

1:30-1:45 PM

De-risking therapeutic target identification and validation through human translational studies

Kalpana Merchant, PhD, TransThera Consulting Co.

1:45-2:00 PM

A molecular network map of the aging brain: a framework with which to integrate genetics and multi-omic data to deconstruct immune responses involved in neurodegeneration

Phillip DeJager, MD PhD, Harvard Medical School

2:00-2:15 PM

Treating the Network: A systems approach to neurotherapies

James Schwaber, PhD, Jefferson University

2:15-2:30 PM

Models spanning Genes, Cells and Brains in Alzheimer's disease - progress and a proposal

Chris Gaiteri, PhD, Rush Medical College, Rush University

2:30-2:45 PM

Ex Vivo phenotypic model systems in target ID for motor neuron disorders

Steve Finkbeiner, MD PhD, Gladstone Institute of Neurological Disease

2:45-3:00 PM

Perspectives on phenotypic screening and target identification

Susanne Swalley, PhD Biogen


Application of Systems Pharmacology to PK/PD, Prediction of Adverse Events and Systems Medicine

Chair: Katya Tsaioun, PhD, Johns Hopkins School of Public Health 3:15 pm - 4:15 pm
07/26/2017    

Time

Event

Presenters

3:15-3:30 PM

Systems Medicine and Biomedical Informatics

Joel Dudley, PhD, Icahn School of Medicine, Mount Sinai

3:30-3:45 PM

Strategies to minimize the risk of failure in the clinic due to insufficient brain exposure

Katya Tsaioun, PhD, Johns Hopkins School of Public Health

3:45-4:00 PM

From Big Data to Smart Data in CNS: QSP provides concrete and actionable knowledge for improving drug discovery and development

Hugo Geerts, PhD, In Silico Biosciences

4:00-4:15 PM

Systems pharmacology and modeling for predictive assessment of drug safety

Jane Bai, PhD, Food and Drug Administration


Biomarker Discovery and Validation

Chair: Allan Levey, MD, PhD, Emory University 4:15 pm -5:30 pm
07/26/2017      

Time

Event

Presenters

4:15-4:30 PM

Pharmacometabolomics Pharmacogenomics Enabling Tools for Quantitative Systems Pharmacology 

Rima Kaddurah-Daouk, PhD, Duke University

4:30-4:45 PM

Proteomics and systems biology discovery of biomarkers for neurodegenerative disorders

Allan Levey, MD, PhD, Emory University

4:45-5:00 PM

Current status of functional MRI as a neuroimaging biomarker for neurotherapeutics development

Owen Carmichael, PhD, Pennington Biomedical Research Center

5:00-5:15 PM

Can imaging biomarkers inform medications development for nicotine withdrawal, craving and relapse?

Elliott Stein, PhD, NIDA

5:15-5:30 PM

Biomarkers, modeling and therapeutic targets:  The CFS/ME and GWI Story

Nancy Klimas, MD, Nova Southeastern University


Day 1 Summary/Next Steps

Piet van der Graaf, PhD, Certara, Workshop Co-Chair, MA Pelleymounter, PhD, NINDS, 5:30-5:45 pm
07/26/2017

Poster Session/Wine and Cheese

5:45 pm - 7:00 pm
07/26/2017

Overview of Day 2 Goals and Logistics

8:30 am - 8:45 am Suzana Petanceska, PhD, NIA, Workshop Co-Chair
07/27/2017

Technical Advances and Data Resources

Chair: John Wikswo, PhD, Vanderbilt University 8:45 am -10:00 am
07/27/2017        

Time

Event

Presenters

8:45-9:00 AM

Organs-on-chips and microphysiological systems as models for quantitative systems pharmacology and the development of neurotherapeutics

John Wikswo, PhD, Vanderbilt University

9:00-9:15 AM

Making a case for the role of tissue-engineered models of the neurovasculature in systems pharmacology

Peter Searson, PhD, Johns Hopkins School of Medicine

9:15-9:30 AM

Predicting molecular phenotypes using statistical learning

James Baurley, PhD, Biorealm Research

9:30-9:45 AM

Combining cell biology with micro-engineered environments

Chris Hinojosa, Emulate, Inc.

9:45-10:00 AM

Open ecosystems for systems biology applications in target discovery

Lara Mangravite, PhD, Sage Bionetworks


Panel Discussion: Where is a Systems Approach Working and Where are the Gaps?

Panel Session Chair: Roberta Brinton, PhD, University of Arizona 10:20 am -10:50 am
07/27/2017

Panel Recommendations: Importance and Feasibility of QSP to Neurotherapeutics

Panel Session Chair: Piet van der Graaf, PhD, Certera 10:50 am -11:20 am
07/27/2017

Workshop Summary/Final Participant Comments

Workshop organizers:Piet van der Graaf, Mary Ann Pelleymounter and Suzana Petanceska 11:20-11:50 am
07/27/2017
Version: 2.0.0